University of Toronto Institute of Biomaterials and Biomedical Engineering

• J. Andrysek
• J. Audet
• B.L. Bardakjian
• E. Biddiss
• W. Chan
• T. Chau
• J.E. Davies
• A.C. Easty
• M. Eizenman
• R. Fernandez-Gonzalez
• G.R. Fernie
• P.M. Gilbert
• M.D. Grynpas
• R.A. Kandel
• D. Kilkenny
• O. Levi
• K. Masani
• A. McGuigan
• A. Mihailidis
• M.K. Nagai
• M.R. Popovic
• M. Radisic
• J. Rocheleau
• J.P. Santerre
• M.V. Sefton
• M.S. Shoichet
• C.A. Simmons
• E.D. Sone
• D.A. Steinman
• P. Trbovich
• K. Truong
• A. Wheeler
• W. Wong
• C.M. Yip
• P. Yoo
• L. You
• P. Zandstra
• J. Zariffa

K. Truong

Associate Professor

• Institute of Biomaterials and Biomedical Engineering
• Edward S. Rogers Department of Electrical and Computer Engineering
• Interim Co-Chair, Biomedical Engineering Undergraduate Option (IBBME)
  

Contact Information

University of Toronto
Rosebrugh Building, Room 420
Toronto, Ontario
M5S 3G9

Tel:  416-978-7772
Fax:  416-978-4317
Email:  kevin.truong@utoronto.ca
Website: http://individual.utoronto.ca/ktruong/

Research Interests

Cells are continuously processing and reacting to external signals that elicit various responses including cell division, migration, differentiation and death. Decades of research in cell biology has revealed these responses are controlled by cellular signaling pathways that resemble computer networks and electrical circuits. Signaling pathways, however, are composed of a coordinated interaction of proteins mediated by modular domains.

Our lab is interested in elucidating the fundamental rules for the engineering of signaling pathways by mutation and recombination of these basic modular domains. Such studies will ultimately improve our understanding of how pathways function and inspire therapies for inhibiting or regulating certain pathways responsible for illness.

Recent Publications

Split-intein mediated re-assembly of genetically encoded Ca(2+) indicators. Wong SS, Kotera I, Mills E, Suzuki H, Truong K.  Cell Calcium. 2012 Jan. 51(1):57-64.

Engineered regulation of lysozyme by the SH3-CB1 binding interaction. Pham E, Truong K.  Protein Eng Des Sel. 2012 Jun. 25(6):307-11.

Parts-based assembly of synthetic transmembrane proteins in mammalian cells. Nagaraj S, Wong S, Truong K.  ACS Synthetic Biology. 2012 Apr 20. 1(4): 111-117.

Effects of rapamycin-induced oligomerization of parvalbumin, Stim1 and Orai1 in puncta formation. Pham E, Wong SS, Nagaraj S, Truong K.  Cell Calcium. 2012 May. 51(5):418-25.

Engineered Networks of Synthetic and Natural Proteins To Control Cell Migration. Evan Mills, Elizabeth Pham, Seema Nagaraj, and Kevin Truong.  ACS Synthetic Biology 2012 1 (6), 211-220

Ca2+-mediated synthetic biosystems offer protein design versatility, signal specificity, and pathway rewiring. Mills E, Truong K.  Chem Biol. 2011 Dec 23. 18(12):1611-9.