60 St. George Street
BiophysTO Lunchtime Series presents Dr. Anna Erzberger from the University of Rockefeller for a talk on “How to form a mirror-symmetric organ? Surface mechanics of developing sensory hair-cells”
Join us on Wednesday August 28thm 2019 at 2pm at McLennan Physical Laboratories (Room MP606)
Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cell level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging assisted by deep learning, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events—one mediated by biochemical signaling and the other by cellular mechanics—give rise to a novel form of collective cell migration, which produces a mirror-symmetric polarity pattern in the receptor organ.
For more information about this event click here.