BiophysTO Lunchtime Series: Dr. Anna Erzberger

When:
August 28, 2019 @ 2:00 pm – 3:00 pm
2019-08-28T14:00:00-04:00
2019-08-28T15:00:00-04:00
Where:
McLennan Physical Laboratories
60 St. George Street
Room MP606

BiophysTO Lunchtime Series presents Dr. Anna Erzberger from the University of Rockefeller for a talk on “How to form a mirror-symmetric organ? Surface mechanics of developing sensory hair-cells”

Join us on Wednesday August 28thm 2019 at 2pm at McLennan Physical Laboratories (Room MP606)

Abstract:

Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cell level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging assisted by deep learning, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events—one mediated by biochemical signaling and the other by cellular mechanics—give rise to a novel form of collective cell migration, which produces a mirror-symmetric polarity pattern in the receptor organ.

For more information about this event  click here.