40 St. George Street
Lance A Davidson, MSc, PhD
William Kepler Whiteford Professor
Bioengineering, Developmental Biology, and Computational and Systems Biology
University of Pittsburgh
Watch any time-lapse of developing embryos and you will be astounded by the choreography of these self-organizing systems. Tissues coordinate their motion to generate all the multicellular forms that surround us. These motions do not only generate robust geometric forms but are also key to the physiological operation of the organism. The past 20 years have seen a resurgent interest in the role of physical mechanics that drive these movements. More recently, our group and others have been leveraging this knowledge to investigate the role that mechanical 'information' plays during development, guiding cell fate choices as well as cell behaviors. In this talk I will outline fundamental advances in biomechanics of embryonic development in the frog Xenopus laevis and then show how we are using these tools and insights to explore the mechanobiology of early development and how embryos rely on mechanical patterns to drive differentiation. I will conclude by discussing how newly exposed principles of embryonic self-assembly are leading to new insights and technologies for tissue engineering.
Interested in meeting the speaker in person? Sign up for lunch here. There are limited number of spots, you will be admitted based on first-come-first-serve basis.