Wayne Ngo and IBBME UofT

February 28, 2020 @ 12:00 pm – 12:30 pm
Red Seminar Room
Donnelly Building

Event Name: Graduate Seminar Series: Molecular Stream

Graduate Seminar Series for the Institute of Biomaterials and Biomedical Engineering (IBBME). This day is for molecular stream presenters.

Location: Red Seminar Room – Donnelly Building

Presentation Title: DNA-controlled encapsulation of small molecules in protein nanoparticles
Abstract: Nanoparticles can carry therapeutic and imaging agents for disease treatment and diagnosis. However, trapping medical agents in the nanoparticle center requires complex interactions between the small molecules and the carrier material. This limits specific control over how multiple types of molecules are trapped. Here, we used specific nucleotide interactions, independent of the molecule structure, to trap them in nanoparticles. We made nanoparticles containing DNA anchors to capture DNA-conjugated small molecules. By changing the sequences and stoichiometry of DNA anchors, we can control the amount and ratios of small molecules in the nanoparticles. This allows the stoichiometry of molecules trapped in our nanoparticle to be tuned as required by combinatorial therapy and theranostic applications.
Supervisor Name: Warren Chan
Year of Study: 4
Program of Study: PhD

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