Portrait of Chris Yip

Christopher Yip

Professor

BASc (Toronto), PhD (Minnesota), FAAAS, FEIC, PEng

Research Stream: Molecular Engineering

Laboratory Website:
http://bigten.med.utoronto.ca/

Email: christopher.yip@utoronto.ca | Tel: 416 978-7853 | Office: Donnelly Centre (DC), 160 College Street, Room 404

Additional Contact Information

Dean, Faculty of Applied Science & Engineering
Decanal Chair in Innovation

University of Toronto
44 St. George Street
Toronto, Ontario, M5S 2E4
Canada

(416) 978-7853 (office)

Main Appointments

  • Department of Chemical Engineering & Applied Chemistry
  • Institute of Biomaterials & Biomedical Engineering

Additional Appointments

  • Department of Biochemistry
  • Donnelly Centre for Cellular & Biomolecular Research

Research Interests

Molecular self-assembly focusing on protein-ligand and biomolecular complexes and elucidation of the mechanisms associated with the development of solution and solid-state structure and molecular conformation. Study of biomolecular association and ligand-receptor interactions using oriented molecular arrays at interfaces. Application of scanning probe microscopy to the characterization of biomolecular processes and structures.

Research Program

Direct elucidation of the mechanisms governing molecular self-assembly has clear implications for understanding and possibly controlling processes ranging from the crystallization of biomolecules and pharmaceutics to the formation of protein complexes and the interaction of protein and drug molecules with cellular membranes and biomimetic substrates.

The ability to acquire in situ real-space information would thus represent a significant advance towards understanding the kinetics and mechanics of molecular self-assembly.

Our research program focuses on the application of in situ scanning probe microscopy in combination with other biophysical characterization techniques including circular dichroism, light scattering, X-ray scattering, NMR spectroscopy, and infrared and Raman spectroscopy to the study of self-assembled systems ranging from molecular and protein crystallization to the formation of ligand complexes and direct measurement of intermolecular forces.

Collaborations with structural biology and crystallography research groups at the University of Toronto in additional to external programs with pharmaceutical companies offer the opportunity to study a wide variety of biomolecular phenomena and processes of therapeutic interest.